It is important to note that, in some cases, metabolic reprograming of cancer cells is a direct consequence of the genetic hit driving the transformation, as in the case of acute myeloid leukemia, glioma, cholangiocarcinoma and chondrosarcoma, where mutations in TCA cycle enzyme isocitrate dehydrogenases (IDH) are responsible for cancer progression [15]. The gene discussed is IDH3A; the disease is cancer.