EGFR and neoplasm: In co-cultures with EGFR+ tumor cell lines, the levels of degranulation of resting healthy donor-derived NK cells were significantly higher in the presence of either of the bispecific VHHs (C-7 p = 0.016; 7-C p = 0.025 when using A431 as target cells; or C-7 p < 0.0001; 7-C p < 0.0001 when using HCT116 as target cells) (Figure 2A).