For example, in our study, a tumor with a rearranged EWSR1 detected by FISH was initially diagnosed as Ewing’s sarcoma until genomic analysis revealed a EWSR1-CREB1 rearrangement, and the diagnosis was consequently changed to angiomatoid fibrous histiocytoma. Here, CREB1 is linked to histiocytoma, Angiomatoid fibrous.