The main findings of this study are as follows: (i) trans-arterial radio-embolization (TARE) appears to improve overall survival in patients with irresectable intrahepatic cholangiocarcinoma (ICC) compared to the reported survival with standard care in the literature; (ii) CA-19-9, cholinesterase, and tumor burden have predictive value for survival in those patients treated with TARE; (iii) Multiple TARE treatments might further improve survival. Here, BCHE is linked to neoplasm.