Finally, the TN HCI-031 ILC PDX shows widespread metastasis including uterine horns, stomach, liver, brain, kidney, LN, and spontaneous metastasis to the mouse ovary, a common site of ILC metastases, which generated the secondary HCI-031OV PDX that took nine months to reach a tumor diameter of 2 cm. This evidence concerns the gene CCL27 and neoplasm.