TP53 and myelodysplastic syndrome: We analyzed the TP53 mutation pattern of 66 MDS patients in WHO’s International Agency for Research on Cancer (IARC) TP53 Database [43], and a similar mutant pattern of R248Q (9.1%), R273H (6.1%), Y220C (6.1%), and R175H (1.5%) was found (Figure 2A).