Co-occurring somatic mutations were found in 48% of MDS patients harboring TP53 mutations in Cluzeau et al.’s study, in which TET2, DNMT3A, JAK2, ASXL1, U2AF1, PPM1D, SF3B1, and NF1 account for the most frequently concurrent gene mutations, which is similar to Haase et al.’s results [15,60]. The gene discussed is JAK2; the disease is myelodysplastic syndrome.