TP53 and myelodysplastic syndrome: The genomic instability caused by TP53 inactivation was considered the pivotal reason for the accumulated chromosomal rearrangements [38,57], and the karyotype complexity is highly related to the variant allele frequency (VAF) of TP53 [58], which is an independent adverse prognostic factor for OS in MDS patients with TP53 mutations [59].