HAVCR2 and central nervous system cancer: [106] In addition, the effect of Tim-3 inhibition was evaluated in a mouse model of glioblastoma multiforme, and the results showed that treatment with anti-Tim-3 and anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) combination therapy significantly increases survival time and immune memory against glioma cells.