Additionally, therapies inhibiting newly emerging targets, including mucin domain 3 (TIM-3) and indoleamine 2,3-dioxygenase-1 (IDO1), as well as agonistic therapies that target the positive stimulatory immune checkpoint CD40 are showing promising results in the treatment of brain cancer in preclinical and clinical settings [61,62,63]. This evidence concerns the gene CD40 and brain cancer.