TLS positive cases showed association with prolonged overall and recurrence-free survival (RFS) as opposed to TLS negative cases (p = 0.005, HR:3.784; 95% CI 1.498–9.562 and p = 0.014, HR:3.296; 95% CI 1.279–8.490 for OS and RFS, respectively), independently of other known prognosticators, while TLS presence in combination with CD8+ T-cell and CD57+ NK cell density was found to have the highest predictive accuracy. The gene discussed is CD8A; the disease is Tumor Lysis Syndrome.