Opposite results were reported in a study by Nourouzian et al., where atypical memory B-cells (CD27–IgM–IgD–) and B-regs presenting a CD24hiCD38hi phenotype isolated from non-sentinel lymph nodes (LNs) of HNSCC patients were associated with an absence of LN cancer infiltration and lower histological grade, both known as good disease prognosticators [106]. The gene discussed is CD27; the disease is head and neck squamous cell carcinoma.