In the same study, by Lechner et al., CD27+/CD38hi/CD20− plasmablast were also higher in tumor samples and HNSCC PBMCs than in healthy mucosa, while CD27+/CD38hi/CD138hi/CD20− plasma cells showed a differential localization in tumor tissue rather than PBMCs [17]. This evidence concerns the gene CD27 and head and neck squamous cell carcinoma.