In this setting, immune cell subtypes, among T-cells, tumor-associated macrophages and neutrophils, have been widely characterized for their immune-stimulatory (CD3+, CD8+, M1 macrophages, NK cells) or anti-inflammatory function (CD4+/Foxp3+ T cells, myeloid-derived suppressor cells, M2 macrophages, N2 neutrophils) with respective positive or negative effects on HNSCC outcomes [32,33,34], while B-cells have only recently attracted researchers’ interest with inconclusive results regarding their prognostic role, so far [35]. Here, CD8A is linked to head and neck squamous cell carcinoma.