As elegantly shown by uPAR gene-targeted knock-out studies in mice, uPAR-mediated extracellular proteolysis is involved in several physiological and pathological tissue remodeling processes including fibrinolysis, wound healing, tissue regeneration and involution, immune response/inflammatory responses, and tumor progression in the context of malignancy (recently reviewed in [4,16]). Here, PLAUR is linked to neoplasm.