PLAUR and neoplasm: Although impairment of uPAR function or inhibition of its expression was associated with impaired invasive, metastatic, and tumorigenic potential of many tumor models in vitro and in vivo [4,11,12,14,16,17,20,52,57,79,84,85], one study in transgenic mice with uPAR gene ablation showed no pronounced causal effects on disease dissemination by metastasis [86].