Malaria-exposed Kisumu children were more likely to have IFN-γ+ CD4+ T cell responses (84%) to EBNA1 compared to Nandi (66%, p = 0.005) and eBL (40%, p < 0.0001) children; however, the frequency of IFN-γ+ CD8+ T cell responders did not differ (63%, 58% and 50%, respectively). The gene discussed is CD8A; the disease is malaria.