TP53 and astrocytoma (excluding glioblastoma): In order to determine the prognostic role of TP53, we have analysed a large cohort of LGG and designed our study to (i) perform separate survival analysis for astrocytoma and oligodendroglioma; (ii) include only ‘pathogenic’ TP53 mutations in the survival analysis, cross-checked with COSMIC and NCBI databases; (iii) correlate TP53 mutation with other molecular features; (iv) propose a mechanism of the prognostic effects based on TP53 mutation status; and (v) understand the prognostic mechanism using available LGG datasets.