TP53 and astrocytoma (excluding glioblastoma): In the multivariate analysis of PFS, TP53 codon 273 mutants were no longer a significant prognostic factor; however, multivariate analysis confirmed that TP53 mutation in codon 273 is an independent prognostic factor for OS in astrocytoma (HR (95% CI): 0.169 (0.036–0.766), p = 0.021) (Table 4).