TP53 and astrocytoma (excluding glioblastoma): In the MSKCC astrocytoma dataset, both ‘other’ TP53 and codon 273 mutant cases showed improved OS and PFS compared to WT, with the codon 273 mutant group showing the most improved OS and PFS among the three groups (Figure 3C,D) (OS: WT = 30 mo., other = 140 mo., codon 273 = 260 mo., p < 0.0001) (PFS: WT = 10 mo., other = 80 mo., codon 273 = 110 mo., p < 0.001).