TP73 and head and neck squamous cell carcinoma: On the other hand, ΔN-p63 induces chemo- and radio-resistance in head and neck squamous cell carcinomas via the suppression of p73 [51]; in breast cancer cell lines, the release of TA-p73 is required from ΔN-p63 to enable cisplatin response since ΔN-p63 binds to TA-p73 to inhibit its pro-apoptotic features.