Other transcriptional factors, such as hypoxia-inducible factor(HIF) -1α, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and signal transducer and activator of transcription 3 (STAT3), are also activated via O-GlcNAcylation, resulting in cancer invasion and metastasis in cancers such as NSCLC, cervical cancer, and head and neck cancer [59,64,65]. This evidence concerns the gene STAT3 and cancer.