A possible mechanistic explanation for this upregulation of RAD51 in GBM cell lines comes from a recent published work on CHD4, an ATPase and member of the nucleosome remodeling and deacetylase (NuRD) complex, which also regulates the expression of RAD51; not only the CHD4 complex goes to sites of DNA damage, but it appears that CHD4 also upregulates expression of RAD51 [29]. This evidence concerns the gene DNAH8 and glioblastoma.