HNF4α also inhibits hepatocyte dedifferentiation, proliferation, migration, and malignant transformation by upregulating miR-194 and miR-192, which are negative regulators of cell adhesion and migration, activated leukocyte cell adhesion molecule (Alcam), tumorigenesis and tumor progression (Rap2B and epiregulin (Ereg)), and EMT-related genes (moesin (Msn)) [59]. This evidence concerns the gene RAP2B and neoplasm.