The silencing of HNF1α in hepatocellular carcinoma cells by siRNA impairs their epithelial phenotype, characterized by the decreased expression of epithelial markers, such as E-cadherin, and the increased expression of mesenchymal markers, such as vimentin, and TFs involved in EMT like Snail1 and Snail2 [60,61,62]. The gene discussed is VIM; the disease is hepatocellular carcinoma.