Given the fact that only a small portion of patients (18/271, 6.6%) exhibited either apparent (n = 9) or cryptic (n = 9) AC16As in this cohort of inv(16)/t(16;16) AML cases, CBFB rearrangement-causing inv(16) or translocations involving chromosomes 16 are mostly simple, balanced chromosomal aberrations without AC16As in the majority of all inv(16)/t(16;16) AML cases. The gene discussed is CBFB; the disease is acute myeloid leukemia.