CBFB and acute myeloid leukemia: Acute myeloid leukemia (AML) with inv(16)(p13.1q22)/t(16;16)(p13.1;q22), CBFB-MYH11 (heretofore referred to as inv(16)/t(16;16) AML), usually shows monocytic and granulocytic differentiation, is characterized by abnormal eosinophils with large basophilic granules, and it is often associated with favorable overall survival when treated appropriately.