Additional reports from pre-clinical studies also indicated that FOXO3 upregulation is related to HCC oncogenicity via the overexpression of the long noncoding RNAs (lncRNAs) PRR34 antisense RNA 1 (PRR34-AS1) [17] and LOC554202 [30], or by the circular RNA circFBXO11/miR-605 axis [13]. The gene discussed is FOXO3; the disease is hepatocellular carcinoma.