FOXO3 and malignant colon neoplasm: Meanwhile, deregulation of FOXO3 levels has shown to differentially influence lymph node metastasis in invasive ductal carcinoma [32], TNBC [34] and bladder carcinoma [45], finding that the interplay β-catenin-FOXO3 can also behave as a metastasis promoter in colon cancer [46].