With respect to the possible association between FOXO3 expression and the aforementioned clinicopathological parameters in other tumors, an investigation conducted with nasopharyngeal carcinoma samples observed that low FOXO3 expression correlates with advanced clinical stages and higher T stages, apart from lymph node metastasis and distant metastasis [41]. Here, FOXO3 is linked to metastatic malignant neoplasm in the lymph nodes.