Variants of these characteristics were detected in the genes ING4 (patient 153; carcinoid tumor), NF1 (patient 144; neuroblastoma), FANCD2 (patient 143; lymphoma), IGF1R (patient 139; Wilms tumor), ALK (patient 119; leukemia), FAT1 (patient 81; HGG), CHEK2 (patient 78; teratoid/rhabdoid tumor), RET (patient 72; leukemia) and SH2B3 (patient 48; leukemia) (more in Table 2; File S3). The gene discussed is IGF1R; the disease is leukemia.