Aiming at an analysis of samples obtained through biopsy, Vohra and co-workers took advantage of the SERS effect using DNA-functionalised nanorattles, targeting the cytokeratin biomarker RNA, CK14, specific for head and neck squamous cell carcinomas (HNSCC) and micrometastases in lymph nodes [129]. This evidence concerns the gene KRT14 and head and neck squamous cell carcinoma.