The secretion of pro-inflammatory cytokines, the extracellular release of HMGB1 and ATP, and the surface exposure of calreticulin and ERp57 consist of the main biomarkers for the induction of ICD and operate as “find me” signals for the induction of the clearing of dying cancer cells by phagocytosis, eliciting an immune response [25,57,86]. The gene discussed is CALR; the disease is cancer.