We have previously described the elevated production of ROS by HT29 cancer cells treated with SeNps, where the induction of apoptosis was analysed by Annexin V-FITC/PI staining as well as the modulation of the expression of apoptosis-related proteins, such as the downregulation of survivin and cIAP-1, and the upregulation of both TRAIL death receptors, DR4 and DR5 [41]. The gene discussed is ANXA5; the disease is cancer.