The impact of an individual microRNA in regulating the expression of multiple gene targets occurs within the stem cell pool (e.g., miR-93 targets JAK1, STAT3, AKT3, SOX4, EZH1 and HMGA2 genes) [55] and in the de-differentiated tumor cells (e.g., miR-210 targets VEGF and RUNX3 gene; and miR-193 family targets CCND1, PTEN, ER gene) [57]. The gene discussed is ESR1; the disease is neoplasm.