HOXC8 and breast cancer: Recent studies have indicated that microRNAs in turn act as the primary controllers of the master regulators, with the expression of the miR-196 family members clearly targeting and suppressing the expression of the HOXC8 gene in breast cancer stem/progenitor cells across all molecular subtypes of breast cancer, leading to the conclusion that HOXC8 is a tumor suppressor gene target [58].