Although no mechanistic studies have elucidated that beer consumption directly affects prognosis in vitro and in vivo, we assume there are possible mechanisms by which alcohol consumption aggravates prognosis by promoting breast cancer cell proliferation, cell transformation, and tumor development via Brf1 gene expression and by increasing the levels of estrogen and androgen, making individuals susceptible to the risk of breast carcinogenesis [104,105,106]. The gene discussed is BRF1; the disease is breast cancer.