CD8A and acute myeloid leukemia: Immune cell abnormalities in AML include proliferation and activation status, misproportion between T effectors (Teffs) and Tregs in favor of the latter, CD8+ T cell exhaustion and senescence [147], increased suppressive macrophages [136], and myeloid-derived suppressor cells (MDSCs), increased release of immunosuppressive factors [123,148], defective antigen presentation by antigen presenting cells (APCs) [123], suppression of natural killer (NK) cell-mediated cytotoxicity [149,150].