VEGFA and cancer: Previous evidence has shown that TAMs are extensively involved in each step of the angiogenic process from degradation of the basement membrane through the production of matrix metalloproteinases (MMPs) and cathepsins to the secretion of proangiogenic growth factors such as VEGF, PDGF, bFGF, and chemokines CCL2 and CXCL8 that provide the vascular network critical for cancer cell growth and dissemination [42,43].