CSF1R and melanoma: Blockage of CSF-1R with PLX3397 not only improved the efficacy of adoptive cell therapy through inhibition of immunosuppressive macrophage recruitment and activation in murine melanoma but also potentiated the response of xenograft glioblastoma to ionizing radiation (IR) by preventing differentiation and pro-tumoral activation of IR-recruited monocytes in mice [124,125].