IL-4 and IL-13, synthesized by CD4+ T cells and/or tumor cells act on infiltrating macrophages through intracellular Stat6 and PI3K signaling to promote an immunosuppressive TAM phenotype while IL-10 produced by regulatory T cells (Treg) also participates in the activation of the TAM phenotype via the actions of Stat3. The gene discussed is IL10; the disease is neoplasm.