TAMs are the primary source of cytokine IL-10 within the tumor microenvironment such as in mammary carcinomas, and can indirectly blunt CD8+ T cell responses by inhibiting DC production of IL-12 or directly on CD4+ T cells, inhibiting proliferation and production of IL-2, IFN-γ, and TNF-α, resulting in suppressing proinflammatory responses within the tumor microenvironment [63]. This evidence concerns the gene CD4 and neoplasm.