In a recent study, Li et al. reported that cancer-associated fibroblast-derived CXCL12 attracts M2-polarized monocytes/macrophages and blocking of C-X-C motif chemokine receptor 4 (CXCR4), the receptor of CXCL12 results in significantly reduced infiltration of pro-tumorigenic TAMs [114]. This evidence concerns the gene CXCL12 and cancer.