SOX2 and breast carcinoma: Yang et al. reported that gene signatures representing CSC properties (Sox-2, Oct-4, Nanog, AbcG2 and Sca-1) were found to be upregulated by TAMs via a paracrine EGFR/Stat3/Sox2 signaling pathway, resulting in increased drug efflux capacity and resistance to chemotherapy in murine breast cancer cells [40].