Intriguingly, different studies have found that TRIB3 can exert both oncogenic [18,19,20,21,22,23,24] and onco-suppressive [16,25,26,27,28,29,30] actions in different cancer types, which suggest that the impact of TRIB3 dysregulation in tumorigenesis might be determined by the cellular context. The gene discussed is TRIB3; the disease is cancer.