Interestingly, although nuclear p-STAT3 was involved in EZH2 transactivating action, p-STAT3 as well as STAT3 were not methylated in PDAC, which is different from other cancer cell types that methylated STAT3 by EZH2 is involved in tumorigenesis of glioblastoma stem-like cells [14]. Here, STAT3 is linked to cancer.