The mRNA targets of the ‘MITF-low’ hub, including miR-125b, showed enrichment for involvement in oxidative phosphorylation, which is consistent with prior evidence implicating miR-125b as a regulator of mitochondrial metabolism [41,42,43], and numerous studies suggesting lower proliferative activity of melanoma cells in ‘MITF-low’ phenotypic states [44,45,46]. This evidence concerns the gene MITF and melanoma.