The GSEA of the mRNAs which were inversely correlated with the larger network identified striking similarities with the enrichments seen in our analysis of the TCGA melanoma ‘keratin’ network, sharing 6 of the top 10 enriched gene sets, including EMT, UV-response DN, apical junction, TNFA signaling via NFkB, hypoxia and TGF-beta signaling (Table S6). Here, NFKB1 is linked to melanoma.