Concerning the SWI/SNF complex: Mutations of the SWI/SNF complex subunit genes have been found in 12–23% of human PDAC cases and reduced or lost expression of BRG1 (encoding Brahma protein-like 1) was observed in human IPMN [87]. Here, SMARCA4 is linked to pancreatic intraductal papillary-mucinous neoplasm.