Male patients (5-year OS: 97.6% vs. 98.2%, p = 0.021) and those with preoperative CEA levels ≥2.5 ng/mL (5-year OS: 97.2% vs. 94.1%, p = 0.002) presented significantly lower survival rates in colon cancer. This evidence concerns the gene CEACAM5 and malignant colon neoplasm.