Figure 7 shows that the cytokine profile of R-MΦs differs from that of GM-MΦs by the secretion of higher levels of chemokines, such as CCL20, CCL19, IL-6, and IL-27. The crucial role played by CCL19 in the immune response is illustrated by its ability with IL-7 to promote tumor infiltration by T cells and dendritic cells and to improve the therapeutic effect of CAR-T cells against solid tumors [81] or multiple myeloma [82]. This evidence concerns the gene IL27 and plasma cell myeloma.