CSF2 and acute myeloid leukemia: Taken together, our results indicate that CSF1R plays a critical role in the polarization of HD M-MΦs and of allogeneic HDAML- or autologous AML-MΦs toward a protumoral M2-like phenotype and that inhibiting the CSF1R activity, in the presence of GM-CSF, efficiently reverses MΦ orientation.