To determine the cell-type-specific activation of IFN signaling in tumor and nontumor cells, we analyzed publicly available human glioma single-cell RNA-seq (scRNA-seq) datasets from the three studies by Neftel et al. (GSE131928) [36], Darmanis et al. (GSE84465) [35], and Yu et al. (GSE117891) [37]. Here, IFNA1 is linked to central nervous system cancer.