The largest and most extensive analysis of the clinical characteristics of ir thyroid disorders to date based on the WHO Global Database by Bai et al. revealed an earlier time of onset of hypothyroidism related to anti-CTLA-4 mAbs compared to anti-PD mAbs, but the time of onset of hyperthyroidism was similar for these two treatments. The gene discussed is CTLA4; the disease is hypothyroidism.