IFNG and endocrine system disorder: This hypothesis is strengthened by evidence showing: (a) a cross-reactivity of T cells (T cells against both tumor antigens and antigens in tissues that are affected by irAEs; (b) increased levels of interferon gamma (IFNγ)-inducible chemokines, such as CXCL9 and CXCL10, which are chemotactic attractors for T cells; (c) the contribution of antibody-dependent cell-mediated cytotoxicity (ADCC); and (d) the association of ir endocrinopathies with the HLA-DR allele, known to increase the risk of autoimmune endocrinopathies [15].