Especially, thyroiditis plus pneumonitis, thyroiditis plus hepatitis, and thyroiditis plus dermatitis ranked first, second, and fourth among the multisystem irAEs patterns, with incidences of 14%, 10%, and 8%, respectively, according to a recent retrospective cohort study in five academic institutions worldwide, enrolling 623 patients with stage III/IV NSCLC treated with anti-PD-(L)1 mAbs [79]. This evidence concerns the gene CD274 and thyroid gland disorder.