TNF and Autoimmunity: Protein antigens were highly expressed in tissues involved in irAEs and were implicated in pathways that correlate with immunity–autoimmunity, such as “apoptosis”, “tumor necrosis factor-a (TNF-a) signaling”, the “interleukin-1 (IL-1) pathway”, and “Toll-like receptor (TLR) signaling” [18].