Our attempt to discover essential interferon-stimulated genes mediating the glioblastoma multiforme sensitivity to oncolytic viruses demonstrated that suppression of MX1, OAS2, IFIT3, and PLSCR1, and overexpression of PLSCR1, encoding crucial components of antiviral response to type I interferons, does not necessarily result in acquiring an increased sensitivity to enteroviruses or enhanced virus replication. The gene discussed is PLSCR1; the disease is glioblastoma.