Transcriptomic analysis of GBM cultures (GBM3821, GBM4446, GBM5522, and GBM4114) also revealed quantitative changes in key regulators and members of the JAK-STAT and RIG-I-like receptors’ signaling cascades, which correlated with CPE in the VSV-I sensitivity tests after treatments with IFNs. The gene discussed is SOAT1; the disease is glioblastoma.