Although histone H3 genes are not consistently mutated in adult supratentorial GBs, Gallo et al. reported that glioma stem cells (GSCs), which are largely responsible for GB recurrence [22], exhibited a reduction in the expression of H3-3B mRNA in culture as a plausible mechanism explaining cellular self-renewal and tumor perpetuation [23]. The gene discussed is H3-3B; the disease is glioma.