Univariate analysis showed that BC subtypes (p < 0.001), Ser_IP-10 level (HR = 2.16, 95% CI = 1.02–4.54, p =  0.043), Ser_MMP-1 level (HR = 2.13, 95% CI = 1.02–4.47, p =  0.044), and Exo_NGF level (HR = 2.5, 95% CI = 1.18–5.31, p =  0.017) were significant prognostic factors for OS. This evidence concerns the gene MMP1 and breast cancer.