The binding of ligand NGF with tropomyosin receptor tyrosine kinases A (TrkA) and the TNF-receptor family member p75NTR (NGFR) activates downstream pathways, such as RAS/MAPK and PI3 kinase, resulting in increased cell proliferation and survival of human breast cancer cells [47,48,49,50]. The gene discussed is NGF; the disease is breast cancer.