NFE2L2 and cancer: Very interesting to note is the determination that PBQC, an oxidized form of 7-diethylamino-3-(2′,5′-dihydroxyphenyl)coumarin (50), is a new nuclear factor-erythroid 2-related factor 2 (Nrf2) activator, which is a key factor involved in the regulation of cancer cell growth by the expression of pro-apoptosis genes [130].