In accordance with our findings, previous studies indicated that anticancer agents inhibited tumor growth, induced autophagy, and suppressed the JAK2/STAT3 pathway, while the autophagy inhibitor CQ enhanced this effect [42,43,44,45]; however, the mechanisms remain unclear, because the RAGE and STAT3 pathways are also regulated by various factors, including HMGB1, NF-κB, fibroblast-specific protein 1 (FSP1), SOCS3, CXCR3, etc. [46,47,48,49,50]. Here, HMGB1 is linked to neoplasm.