Ingenuity pathway analysis (IPA) revealed that the upregulated proteins hornerin (HRNR), tropomyosin alpha-1 chain (TPM1), annexin A (ANXA2), and protein-disulfide isomerase (PDI) were associated with breast or gynecological cancer, breast carcinoma, and inflammation of organ. The gene discussed is HRNR; the disease is breast carcinoma.