β-Caryophyllene, β -caryophyllene oxide, and α-humulene, have been also found to induce apoptotic cancer cell death through the regulation of different pathways, such as JAK1/STAT3, NF-kB and PI3K/AKT/mTOR/S6K1 [4,25,33,34]. The gene discussed is AKT1; the disease is cancer.