It should be emphasized that an increased secretion of Il-1β, Il-6, Il-12 and RANTES chemokines and, at the same time, a reduced secretion of anti-inflammatory Il-10 due to hypercholesterolaemia, oxidative stress and hyperglycaemia, resulted in vascular wall damage and the progression of atherosclerosis [3,4,5]. The gene discussed is IL6; the disease is atherosclerosis.