The constitutive activation of PI3K/Akt signalling was found in many types of tumours, including breast and prostate tumours, ovarian, uteri tumours etc. Being the central player in the transferring of mitogen stimuli, PI3K/Akt signalling is involved in the compensatory overcoming of the drug-induced growth block [45,46,47]. The gene discussed is AKT1; the disease is neoplasm.