Ginsenoside Re significantly increased the activities of SOD (p < 0.05) and decreased the level of MDA (p < 0.05) in T2DM rats, and the activities of CAT also tended to increase, but the difference was not statistically significant, indicating that ginsenoside Re could mitigate the oxidative stress in T2DM rats. Here, CAT is linked to type 2 diabetes mellitus.