Dapholosericin A (133), a tigliane diterpene from the EtOAc extract of D. holosericea, was discovered to be a moderate acetylcholinesterase (AChE) inhibitor at a concentration of 100 μM, which suggested its potential usage in the mediation of Alzheimer’s disease [65]. Here, ACHE is linked to early-onset autosomal dominant Alzheimer disease.