ANXA1 and rheumatoid arthritis: Among the numerous and different cells types, cytokines and endogenous mediators involved in the pathogenesis of RA, special attention has been paid to annexin A1 (AnxA1) [5], an anti-inflammatory mediator able to inhibit leukocyte recruitment, pro-inflammatory cytokine expression, and joint inflammation, as demonstrated in several RA animal models [5,6].