IL1B and rheumatoid arthritis: EGCG, a powerful compound from Camellia sinensis, had anti-RA properties for human rheumatoid joint pain aggravating synovial fibroblasts (RASF), when administered for 12 h, by downregulating epithelial neutrophil-starting peptide (ENA)-78, Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted (RANTES), and growth-regulated oncogene (GRO)-IL-1-impelled MMP-2 [49].