SPARC and prostate carcinoma: For example, refactored M13 bacteriophage for targeted imaging and drug delivery to prostate cancer cells in vitro has been developed: doxorubicin was attached to the M13 bacteriophage major coat protein pVIII, and the minor coat protein pIII displayed a peptide with affinity for SPARC (secreted protein, acidic, and rich in cysteine).