This study aims to assess whether CPO-B attenuates MPP+-induced cytotoxicity in the dopaminergic cell SH-SY5Y, a cell model of PD, and to explore whether it exerts neuroprotection through activating the Erk1/2 signaling pathway and modulating the dysregulation between pro-apoptotic and anti-apoptotic proteins. This evidence concerns the gene MAPK3 and Parkinson disease.