Although ALS and frontotemporal dementia (FTD) are both linked to TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons, there are no works directly linking air pollution with impact on FTD risk, except Numan et al. [51], addressing oxidative stress and autophagy in FTD and other neurodegenerative diseases, and the work of Calderón-Garcidueñas and coworkers of quadruple aberrant protein pathology, including TDP-43 in children and young MMC adults [26]. The gene discussed is TARDBP; the disease is frontotemporal dementia.