In vitro, Yamada et al. demonstrated that exposure to phosphoglycerol dihydroceramide produced by P. gingivalis (PGDHC) increased Aβ peptide secretion in a dose-dependent manner in the Chinese hamster ovary-7WD10 cells, stably expressing wild-type human amyloid precursor protein (APP) and induced specific phosphorylation of Tau protein in a dose-dependent manner in human neuroblastoma cells [40]. Here, APP is linked to neuroblastoma.