LPAR6 and cancer: We also found that late-stage (stage 4) with the lowest promoter methylation showed levels of LPAR6 in LUSC whereas it is the highest methylation level in entire cancer progress in LUAD cohorts (stage 1–4) (Figure 3A,E), and the lowest promoter methylation levels of LPAR6 appears in an earlier stage (stage 2) of LUAD while in the late stage of LUSC.