These findings were further confirmed in another study that showed that HIF-1α upregulated P2Y2 expression at mRNA and protein levels and, thereby, prolonged the viability of human hepatocellular carcinoma (HHC), whereas treatment of HCC with a selective P2Y2 antagonist MRS2312 led to a reduction in cell viability [87]. Here, P2RY2 is linked to hepatocellular carcinoma.