Compared to WT mice, P2Y2-KO mice displayed a larger infarct size and worse heart function in a myocardial infarction model, and in vivo treatment with MRS2768, a P2Y2 specific agonist, protected the heart from ischemic damage [77,78] and prevented vascular calcification [79,80]. This evidence concerns the gene P2RY2 and myocardial infarction.